Although P-CIP2 interacts with stathmin, it does not phosphorylate stathmin. Site-directed mutagenesis, phosphoamino acid analysis, and use of synthetic peptides demonstrate that PAM-Ser949 is the major site phosphorylated by P-CIP2. Although P-CIP2 interacts with stathmin, it does not phosphorylate stathmin.
P-CIP2 is a highly selective kinase, phosphorylating the cytosolic domain of PAM, but not the corresponding region of furin or carboxypeptidase D. Although P-CIP2 interacts with stathmin, it does not phosphorylate stathmin. P-CIP2 is a highly selective kinase, phosphorylating the cytosolic domain of PAM, but not the corresponding region of furin or carboxypeptidase D.
This is known as the ‘taxonomic identifier’ or ‘taxid’. This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism.
It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first. This subsection of the Names and taxonomy section is present for entries that are part of a proteome, i.e.
Based on subcellular fractionation, the 47-k Da P-CIP2 protein is mostly cytosolic. P-CIP2 is a highly selective kinase, phosphorylating the cytosolic domain of PAM, but not the corresponding region of furin or carboxypeptidase D. Based on subcellular fractionation, the 47-k Da P-CIP2 protein is mostly cytosolic.
In situ hybridization and immunocytochemistry show that P-CIP2 is expressed widely throughout the brain; PAM and P-CIP2 are expressed in the same neurons. Based on subcellular fractionation, the 47-k Da P-CIP2 protein is mostly cytosolic. In situ hybridization and immunocytochemistry show that P-CIP2 is expressed widely throughout the brain; PAM and P-CIP2 are expressed in the same neurons.
These elements correspond to the DSSP secondary structure code ‘T’. View protein in Inter Pro IPR011042 6-blade_b-propeller_Tol B-like IPR014784 Cu2_ascorb_m Oase-like_CIPR020611 Cu2_ascorb_m Oase_CS-1IPR014783 Cu2_ascorb_m Oase_CS-2IPR000323 Cu2_ascorb_m Oase_NIPR036939 Cu2_ascorb_m Oase_N_sf IPR024548 Cu2_monoox_CIPR001258 NHL_repeat IPR013017 NHL_repeat_subgr IPR000720 PHM/PALIPR008977 PHM/PNGase_F_dom_sf This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). However Uni Prot KB may contain entries with identical sequences in case of multiple genes (paralogs). The algorithm is described in the ISO 3309 standard. The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.
Additionally, this section gives relevant information on each alternative protein isoform. 10 20 30 40 50MAGRARSGLL LLLLGLLALQ SSCLAFRSPL SVFKRFKETT RSFSNECLGT 60 70 80 90 100IGPVTPLDAS DFALDIRMPG VTPKESDTYF CMSMRLPVDE EAFVIDFKPR 110 120 130 140 150ASMDTVHHML LFGCNMPSST GSYWFCDEGT CTDKANILYA WARNAPPTRL 160 170 180 190 200PKGVGFRVGG ETGSKYFVLQ VHYGDISAFR DNHKDCSGVS VHLTRVPQPL 210 220 230 240 250IAGMYLMMSV DTVIPPGEKV VNADISCQYK MYPMHVFAYR VHTHHLGKVV 260 270 280 290 300SGYRVRNGQW TLIGRQNPQL PQAFYPVEHP VDVTFGDILA ARCVFTGEGR 310 320 330 340 350TEATHIGGTS SDEMCNLYIM YYMEAKYALS FMTCTKNVAP DMFRTIPAEA 360 370 380 390 400NIPIPVKPDM VMMHGHHKEA ENKEKSALMQ QPKQGEEEVL EQGDFYSLLS 410 420 430 440 450KLLGEREDVH VHKYNPTEKT ESGSDLVAEI ANVVQKKDLG RSDAREGAEH 460 470 480 490 500EEWGNAILVR DRIHRFHQLE STLRPAESRA FSFQQPGEGP WEPEPSGDFH 510 520 530 540 550VEEELDWPGV YLLPGQVSGV ALDSKNNLVI FHRGDHVWDG NSFDSKFVYQ 560 570 580 590 600QRGLGPIEED TILVIDPNNA EILQSSGKNL FYLPHGLSID TDGNYWVTDV 610 620 630 640 650ALHQVFKLDP HSKEGPLLIL GRSMQPGSDQ NHFCQPTDVA VEPSTGAVFV 660 670 680 690 700SDGYCNSRIV QFSPSGKFVT QWGEESSGSS PRPGQFSVPH SLALVPHLDQ 710 720 730 740 750LCVADRENGR IQCFKTDTKE FVREIKHASF GRNVFAISYI PGFLFAVNGK 760 770 780 790 800PYFGDQEPVQ GFVMNFSSGE IIDVFKPVRK HFDMPHDIVA SEDGTVYIGD 810 820 830 840 850AHTNTVWKFT LTEKMEHRSV KKAGIEVQEI KEAEAVVEPK VENKPTSSEL 860 870 880 890 900QKMQEKQKLS TEPGSGVSVV LITTLLVIPV LVLLAIVMFI RWKKSRAFGD 910 920 930 940 950HDRKLESSSG RVLGRFRGKG SGGLNLGNFF ASRKGYSRKG FDRVSTEGSD 960 970 QEKDEDDGTE SEEEYSAPLP KPAPSS The checksum is a form of redundancy check that is calculated from the sequence. It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low. The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x x 1. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display. This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s).
271, 2863628640); the partial amino acid sequence of P-CIP2 suggested that it was a protein kinase.
Annotation score:5 out of 5 The annotation score provides a heuristic measure of the annotation content of a Uni Prot KB entry or proteome.
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